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. 2012 Jul 26;2:534. doi: 10.1038/srep00534

Figure 3. Induction of interleukin-6 (IL-6) and interferon-α (IFN-α) in peripheral blood mononuclear cells (PBMCs).

Figure 3

Cells were stimulated with 0.65 μM free CpG ODN2006x3-PD molecules or 80 μg/mL allylamine-modified Si-NPs loaded with CpG ODN2006x3-PD at a concentration corresponding to 0.65 μM in the culture medium. (a) Free CpG ODN2006x3-PD molecules stimulated IL-6 induction, but CpG ODN2006x3-PD bound electrostatically to allylamine-modified Si-NPs inhibited the induction. n = 3. **, p < 0.05. ND, not detected. (b) IFN-α was induced by CpG ODN2006x3-PD bound electrostatically to allylamine-modified Si-NPs but not by free CpG ODN2006x3-PD. n = 3. ND, not detected; PBS, phosphate-buffered saline.