Transmission electron micrographs (TEM) of Candida albicans strain 78 incubated with 50 µg/ml RsAFP2 for 16 h at room temperature. Control cells have normal ultrastructural profiles with a continuous cytoplasmic membrane, a compact cell wall with an external fibrilar layer, and budding cells with short-sized necks (arrows in panel A). RsAFP2-treated cells show ultrastructural alterations, such as an aberrant budding profile with a large neck size of the buds (arrows in panel B), altered cell shape with abnormal cell wall structure (arrows in panel C), and absence of the outermost wall layer in some areas (arrows in panel D). Panels E–G represent large magnification images of B, C and D, respectively. Bars: 0.3 µm.