Table 1.
The data represent 63 gene products, the function of which is suppressed in calcified versus non-calcified degenerated aortic valves. There are following functional groups: energy metabolism, proteins responsible for cytoskeleton formation, matrix building, and tissue remodelling [7]
| GeneBank Accession / SwissProt Accession | Gene (protein) name / function | |
|---|---|---|
| I. Energy metabolism proteins (40 genes) | ||
| S70154 | Q16146 | acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase) |
| D90228 | P24752 | acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) |
| L07033 | P35914 | 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria) |
| X83618 | P54868 | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) |
| U62961 | P55809 | 3-oxoacid CoA transferase |
| M93107 | Q02338 | 3-hydroxybutyrate dehydrogenase (heart, mitochondrial) |
| X17025 | Q13907 | isopentenyl-diphosphate delta isomerase |
| X69141 | P37268 | farnesyl-diphosphate farnesyltransferase 1 |
| M88468 | Q03426 | mevalonate kinase (mevalonic aciduria) |
| U49260 | P53602 | mevalonate (diphospho) decarboxylase |
| D78130 | Q14534 | squalene epoxidase |
| D63807 | P48449 | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) |
| Q9UEZ1 | ||
| AF034544 | O60492 | 7-dehydrocholesterol reductase |
| U60205 | Q15800 | sterol-C4-methyl oxidase-like |
| M67466 | P14060 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 |
| Q14545 | ||
| P26439 | ||
| Y09501 | P00387 | diaphorase (NADH) (cytochrome b-5 reductase) |
| L21934 | P35610 | sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1 |
| R07932 | diacylglycerol O-acyltransferase homolog 1 (mouse) | |
| M74047 | P31213 | steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) |
| L33179 | Q13713 | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide |
| P40394 | ||
| M68895 | P28332 | alcohol dehydrogenase 6 (class V) |
| M63967 | P30837 | aldehyde dehydrogenase 1 family, member B1 |
| X05409 | P05091 | aldehyde dehydrogenase 2 family (mitochondrial) |
| Q03639 | ||
| M73704 | Q00169 | phosphotidylinositol transfer protein |
| L34081 | Q14032 | bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase) |
| U47105 | Q15738 | NAD(P) dependent steroid dehydrogenase-like; H105e3 |
| X05130 | P30037 | procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide (protein disulfide isomerase; thyroid hormone binding protein p55) |
| P32079 | ||
| Q15205 | ||
| P07237 | ||
| U12424 | P43304 | glycerol-3-phosphate dehydrogenase 2 (mitochondrial) |
| L34041 | P21695 | glycerol-3-phosphate dehydrogenase 1 (soluble) |
| D88308 | O14975 | fatty-acid-Coenzyme A ligase, very long-chain 1 |
| L09229 | P41215 | fatty-acid-Coenzyme A ligase, long-chain 1 |
| P33121 | ||
| X83368 | P48736 | phosphoinositide-3-kinase, catalytic, gamma polypeptide |
| S67334 | P42338 | phosphoinositide-3-kinase, catalytic, beta polypeptide |
| X66922 | P29218 | inositol(myo)-1(or 4)-monophosphatase 1 |
| M74161 | P32019 | inositol polyphosphate-5-phosphatase, 75kD |
| L08488 | P49441 | inositol polyphosphate-1-phosphatase |
| D16481 | P55084 | hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit |
| U40002 | Q05469 | lipase, hormone-sensitive |
| M72393 | P47712 | phospholipase A2, group IVA (cytosolic, calcium-dependent) |
| U20157 | Q15692 | phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) |
| Q13093 | ||
| II. Cytoskeleton formation, ECM-building & tissue-remodelling proteins (23 genes) | ||
| X58141 | P35611 | adducin 1 (alpha) |
| X58199 | P35612 | adducin 2 (beta) |
| M58018 | P12883 | myosin, heavy polypeptide 7, cardiac muscle, beta |
| Q14904 | ||
| Q16579 | ||
| M63603 | P26678 | Phospholamban |
| X92762 | Q16635 | tafazzin (cardiomyopathy, dilated 3A (X-linked); endocardial fibroelastosis 2; Barth syndrome) |
| X56134 | P08670 | vimentin |
| J03209 | P08254 P09238 | matrix metalloproteinase 3 (stromelysin 1, progelatinase) |
| D83646 | P51512 | matrix metalloproteinase 16 (membrane-inserted) |
| X75308 | P45452 | matrix metalloproteinase 13 (collagenase 3) |
| X07819 | P09237 | matrix metalloproteinase 7 (matrilysin, uterine) |
| J05070 | P14780 | matrix metalloproteinase 9 (gelatinase B, 92kD gelatinase, 92kD type IV collagenase) |
| X89576 | Q14850 | matrix metalloproteinase 17 (membrane-inserted) |
| L23808 | P39900 | matrix metalloproteinase 12 (macrophage elastase) |
| J05556 | P22894 | matrix metalloproteinase 8 (neutrophil collagenase) |
| J03210 | P08253 | matrix metalloproteinase 2 (gelatinase A, 72kD gelatinase, 72kD type IV collagenase) |
| X57766 | P24347 | matrix metalloproteinase 11 (stromelysin 3) |
| X03124 | P01033 | tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor) |
| Q14252 | ||
| U14394 | P35625 | tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory) |
| U76456 | Q99727 | tissue inhibitor of metalloproteinase 4 |
| L00073 | P00797 | renin |
| J04144 | P12821 | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 |
| L13977 | P42785 | prolylcarboxypeptidase (angiotensinase C) |
| K02566 | P01043 | kininogen |