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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Am J Psychiatry. 2011 Oct 31;169(1):55–63. doi: 10.1176/appi.ajp.2011.11010126

Table 3.

Regional [11C]DTBZ binding potential (BPND) in healthy controls and chronic cocaine abusers †

Functional subdivision Anatomical subdivision Controls Cocaine abusers Difference p-value
Mean SD Mean SD Mean
Limbic striatum Ventral striatum 2.16 0.30 1.94 0.15 −10.0% 0.0399
Associative striatum 2.34 0.20 2.03 0.16 −13.4% 0.0004
Precommissural dorsal caudate 2.48 0.26 2.08 0.25 −16.3% 0.0007
Postcommissural caudate 1.84 0.22 1.55 0.30 −15.8% 0.0137
Precommissural anterior putamen 2.61 0.18 2.34 0.16 −10.2% 0.0011
Sensori-motor striatum Postcommissural putamen 3.03 0.24 2.68 0.22 −11.5% 0.0014
Whole striatum 2.55 0.20 2.25 0.16 −11.7% 0.0006

Values are mean and standard deviation (SD), n = 12 per group

Associative striatum values are a weighted average of Precommissural dorsal caudate, Postcommissural caudate, and Precommissural anterior putamen; Whole striatum values are a weighted average of the five anatomical subdivisions

p-values are from two-tailed, unpaired t tests

†

BPND data as derived using two-tissue compartment kinetic analysis in n=10 subjects/group and using simplified reference-tissue method in n=2 subjects/group who did not receive an arterial line.