Table 2. Log Reduction in K. pneumoniae CFU by Imipenem in the Presence and Absence of Compound 3d.
Log reduction in CFU/mL as compared to untreated
control |
|||
---|---|---|---|
time (h) | imipenem concn (μg/mL) | imipenem alone | imipenem + 30 μM 3d |
4 | 32 | 4.36 ± 0.06 | >5.0 |
16 | 3.16 ± 0.05 | >5.0 | |
8 | 2.53 ± 0.12 | >5.0 | |
4 | 0.86 ± 0.06 | >5.0 | |
2 | 0.79 ± 0.02 | 3.84 ± 0.12 | |
8 | 32 | 0.92 ± 0.03 | >5.0 |
16 | 0.39 ± 0.05 | >5.0 | |
8 | 0.62 ± 0.07 | >5.0 | |
4 | 0.53 ± 0.01 | 3.71 ± 0.20 | |
2 | 0.38 ± 0.03 | 0.88 ± 0.17 | |
16 | 32 | <0.1 | >5.0 |
16 | <0.1 | >5.0 | |
8 | <0.1 | 2.40 ± 0.19 | |
4 | <0.1 | 0.30 ± 0.08 | |
2 | <0.1 | <0.1 |