Table 1.
Blood flow, gases, and pH
| Strain | WT (n = 8) | tsad−/− (n = 11) |
| mean ± SEM | mean ± SEM | |
| Mean arterial blood pressure (mmHg) | 85 ± 2 | 85 ± 5 |
| Blood flow (ml/min g) | ||
| Pancreas caput | 1.64 ± 0.34 | 2.52 ± 0.33 |
| Pancreas cauda | 1.38 ± 0.27 | 1.17 ± 0.27 |
| Duodenum | 3.19 ± 0.60 | 4.50 ± 0.96 |
| Colon | 2.34 ± 0.33 | 1.11 ± 0.28 |
| Liver (hepatic artery) | 0.02 ± 0.01 | 0.10 ± 0.03 |
| Kidneys | 4.38 ± 0.90 | 4.40 ± 1.07 |
| Adrenal glands | 17.57 ± 4.26 | 18.59 ± 4.95 |
| Cerebrum | 0.74 ± 0.11 | 1.49 ± 0.46 |
| White adipose tissue | 0.05 ± 0.01 | 0.01 ± 0.001 |
| Lungs (= shunted blood) | 0.07 ± 0.04 | 0.04 ± 0.01 |
| Blood gases and pHa | ||
| Blood pH | 7.25 ± 0.03 | 7.28 ± 0.04 |
| PCO2 (kPa) | 6.37 ± 0.32 | 5.06 ± 0.62 |
| Total CO2 (mmol/l) | 22.6 ± 1.2 | 19.0 ± 1.9 |
| PO2 (kPa) | 13.75 ± 0.46 | 11.85 ± 0.98 |
| Oxygen saturation (%) | 96.2 ± 0.9 | 94.1 ± 1.0 |
| S-HCO3- (mmol/l) | 21.0 ± 1.2 | 17.8 ± 1.6 |
| S-Na+ (mmol/l) | 144 ± 1 | 147 ± 1.0 |
| S-K+ (mmol/l) | 5.6 ± 0.2 | 4.7 ± 0.2 |
| Base excess (mmol/l) | －6 ± 2 | －8 ± 1.0 |
| Hemoglobin (g/liter) | 116 ± 4 | 112 ± 5 |
a
Both strains demonstrated slight anesthesia-induced hyperventilation (high PO2, low PCO2, low base excess, and low total CO2). There were no significant differences between the groups.