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. 2012 Jul 2;209(7):1273–1287. doi: 10.1084/jem.20120033

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© 2012 DiGiandomenico et al.

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Figure 6. — Anti-Psl mAb, Cam-003, reduces organ burden after induction of acute pneumonia. BALB/c mice were treated with antibody 24 h before infection with PAO1 (1.1e7 CFU; A), 33356 (1e7 CFU; B), 6294 (6.25e6; C), and 6077 (1e6 CFU; D). 24 h after infection, animals were euthanized, followed by harvesting of organs for identification of viable CFUs. Differences in viable CFU were determined by the Mann-Whitney U test for Cam-003 versus R347. (A) Lung, Cam-003 (45 mg/kg, P = 0.0015; 15 mg/kg, P = 0.0021; 5 mg/kg, P = 0.0015); spleen, Cam-003 (45 mg/kg, P = 0.0120; 15 mg/kg, P = 0.0367); kidneys, Cam-003 (45 mg/kg, P = 0.0092; 15 mg/kg, P = 0.0056; (B) lung, Cam-003 (45 mg/kg, P = 0.0010; 15 mg/kg, P < 0.0001; 5 mg/kg, P = 0.0045); (C) lung, Cam-003 (45 mg/kg, P = 0.0003; 15 mg/kg, P = 0.0039; 5 mg/kg, P = 0.0068); spleen, Cam-003 (45 mg/kg, P = 0.0057; 15 mg/kg, P = 0.0230; 5 mg/kg, P = 0.0012); (D) lung, Cam-003 (45 mg/kg, P = 0.0005; 15 mg/kg, P = 0.0003; 5 mg/kg, P = 0.0007); spleen, Cam-003 (45 mg/kg, P = 0.0015; 15 mg/kg, P = 0.0089; 5 mg/kg, P = 0.0089); kidneys, Cam-003 (45 mg/kg, P = 0.0191; 15 mg/kg, P = 0.0355; 5 mg/kg, P = 0.0021). (A–D) The lungs, spleen, and kidneys from 10 animals (for each antibody-treated group) were used. Results are representative data from two independent experiments for each P. aeruginosa strain.