Table 2.

Biochemical characteristics of rabbits after 8 weeks of RNA interference treatment.

	Controls (n = 5)	siRNA (n = 5)	p-value
Plasma cholesterol (mg/dL)	4800 ± 2074	4689 ± 1687	0.93
Plasma triglycerides (mg/dL)	560 ± 625	212 ± 109	0.35
Free cholesterol (mg/dL)	2638 ± 1115	2287 ± 685	0.28
Alanine-aminotransferase (U/L)	68.8 ± 42.0	92.2 ± 70.8	0.54
Aspartate-aminotransferase (U/L)	57.2 ± 14.8	66.4 ± 26.1	0.56
γ-glutamyl transferase (U/L)	8.4 ± 2.0	11.4 ± 3.0	0.10
Alkaline phosphatase (U/L)	21.2 ± 15.0	16.2 ± 11.0	0.58
C-reactive protein (mg/dL)	N.D.	N.D.
Initial cholesteryl ester transfer (%)	77.2 ± 9.6	80.2 ± 5.1	0.56
Total cholesteryl ester transfer (%)	72.5 ± 25.1	77.8 ± 18.7	0.72
CETP-activity (pmol/μL/h)	76.0 ± 18.5	63.7 ± 6.4	0.20

siRNA = small interfering RNA; N.D. = non detectable.