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. Author manuscript; available in PMC: 2012 Jul 26.
Published in final edited form as: Brain Res. 2008 Apr 7;1217:185–194. doi: 10.1016/j.brainres.2008.03.060

Figure 3. 5-HTT-IR Axons in Diffuse Lewy Body Brain.

Figure 3

5-HTT-IR axons in brains from patients diagnosed with Diffuse Lewy-Body Dementia. A. This picture shows normal appearing 5-HTT-IR axonal bundles in the dorsal aspect of the section just above the inferior colliculus (IC). There is evidence of dystrophic 5-HTT-IR axons in the fiber bundles (arrows). Scale bar is 200µm. B. Normal and abnormal (arrows) terminals in the substantia nigra. Two pigmented nigra neurons can be seen. Scale bar is 50µm. C. Splayed 5-HTT-IR terminals seen in CA3 dendritic region. Scale bar is 50µm. D. Tight clusters of 5-HTT-IR axons in Layer III of entorhinal cortex. The number of labeled fibers is reduced in this region. Scale bar is 50µm. E. Tight cluster of 5-HTT-IR fibers in Layer III of prefrontal cortex. Scale bar is 50µm. F. In deep layers of cortex, aggregates of fibers are found among dystrophic 5-HTT-IR axons with enlarged varicosities. Scale bar is 200µm.