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. Author manuscript; available in PMC: 2012 Jul 26.
Published in final edited form as: Brain Res. 2008 Apr 7;1217:185–194. doi: 10.1016/j.brainres.2008.03.060

Figure 5. 5-HTT-IR Axons in Frontal Lobe Dementia.

Figure 5

5-HTT-IR axons in brains from patients diagnosed with Frontal Lobe Dementia. A. Dense innervation by 5-HTT-IR fibers is seen in the substantia nigra nucleus. No dystrophic 5-HTT-IR fibers seen. Scale bar is 200µm. B. Heavy labeling of the fibers in the medial lemniscal tract. No dystrophic 5-HTT-IR fibers seen. Scale bar is 200µm. C. Enlarged varicosities seen in hilus area of dentate gyrus. Scale bar is 50µm. D. Several splayed and degenerating 5-HTT-IR terminals seen in the upper layer of entorhinal cortex. Note reduced appearance of normal 5-HTT-IR fibers. Scale bar is 50µm. E. Dense clustering and aggregation of 5-HTT-IR axons in layer II–III of the prefrontal cortex. Note normal tangential fibers in layer I. Scale bar is 50µm. F. Enlarged 5-HTT-IR axons are seen in the deeper layers of prefrontal cortex. 5-HTT-IR axonal innervation appears reduced from normal. Scale bar is 50µm.