Table 2. nAChR gene common variant association with nausea severity at 21 days.

SNP ID	A11	A22	Gene	Type	MAF	PAdd3	PDom4
rs2280781	C	T	CHRNB2	5′ UTR	0.101	0.359	0.278
rs4845378	G	T	CHRNB2	intron	0.097	0.259	0.259
rs2072660	T	C	CHRNB2	3′ UTR	0.244	0.004	0.006
rs2072661	G	A	CHRNB2	3′ UTR	0.245	0.006	0.005
rs4292956	C	T	CHRNB2	3′ UTR	0.066	0.056	0.021
rs2472553	G	A	CHRNA2	non-syn	0.139	0.465	0.791
rs13277254	G	A	CHRNB3	up	0.234	0.889	0.837
rs13280301	A	G	CHRNB3	up	0.178	0.948	0.786
rs13277524	G	T	CHRNB3	up	0.234	0.889	0.837
rs6474413	C	T	CHRNB3	up	0.232	0.986	0.896
rs4950	G	A	CHRNB3	5′ UTR	0.236	0.901	0.855
rs2304297	G	C	CHRNA6	3′ UTR	0.244	0.288	0.281
rs71653603	C	T	CHRNA7	syn	0.060	0.878	0.878
rs569207	C	T	CHRNA5	intron	0.196	0.466	0.542
rs16969968	G	A	CHRNA5	non-syn	0.367	0.790	0.698
rs615470	T	C	CHRNA5	3′ UTR	0.381	0.912	0.462
rs8192482	C	T	CHRNA5	3′ UTR	0.368	0.911	0.541
rs564585	A	G	CHRNA5	3′ UTR	0.237	0.786	0.607
rs12899226	T	G	CHRNA3	down	0.052	0.051	0.051
rs660652	A	G	CHRNA3	3′ UTR	0.383	0.929	0.462
rs472054	A	G	CHRNA3	3′ UTR	0.379	0.925	0.475
rs578776	A	G	CHRNA3	3′ UTR	0.247	0.836	0.749
rs1051730	G	A	CHRNA3	syn	0.367	0.802	0.675
rs3743075	T	C	CHRNA3	syn	0.378	0.981	0.533
rs3743074	G	A	CHRNA3	intron	0.378	0.969	0.587
rs8040868	T	C	CHRNA3	syn	0.429	0.376	0.491
rs8192475	C	T	CHRNA3	non-syn	0.050	0.362	0.362
rs12914008	G	A	CHRNB4	non-syn	0.051	0.208	0.208
rs3813567	G	A	CHRNB4	up	0.157	0.781	0.824
rs2302765	T	C	CHRNB1	intron	0.159	0.182	0.142
rs12452047	A	G	CHRNB1	intron	0.166	0.235	0.172
rs7210231	C	A	CHRNB1	intron	0.199	0.268	0.242
rs2302761	C	T	CHRNB1	intron	0.202	0.192	0.183
rs2302763	T	C	CHRNB1	intron	0.164	0.462	0.394
rs2302764	T	C	CHRNB1	3′ UTR	0.160	0.062	0.047
rs3827020	T	C	CHRNA4	intron	0.153	0.160	0.271
rs45442394	G	A	CHRNA4	intron	0.066	0.333	0.235
rs1044397	C	T	CHRNA4	syn	0.460	0.331	0.369
rs1044396	G	A	CHRNA4	syn	0.458	0.180	0.177
rs2229960	A	G	CHRNA4	syn	0.059	0.627	0.681
rs2229959	C	A	CHRNA4	syn	0.122	0.702	0.858
rs1044394	A	G	CHRNA4	syn	0.071	0.985	0.919
rs6090384	T	C	CHRNA4	intron	0.063	0.752	0.814
rs2273505	C	T	CHRNA4	intron	0.066	0.269	0.337
rs2273506	G	A	CHRNA4	syn	0.065	0.358	0.444

¹A1=allele 1;

²A2=allele 2;

³P_Add= P of additive model;

⁴P_Dom= P of dominant model.