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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Pharmacogenomics J. 2011 May 24;12(4):349–358. doi: 10.1038/tpj.2011.19

Table 4. nAChR gene common and rare variant association with nausea severity at 21 days.

MDMR1 Allele Sharing MDMR Weighted Allele Sharing
Gene N SNPs pseudo-F P % variation pseudo-F P % variation
CHRNB2 24 4.70 0.02 0.012 5.58 0.01 0.014
 CHRNB22 5 5.30 0.01 0.013 5.55 0.01 0.014
 CHRNB23 19 1.21 0.42 0.003 0.56 0.44 0.001
CHRNA2 11 0.32 0.68 0.008 1.34 0.26 0.003
CHRNB3 12 0.16 0.77 0.004 −0.01 0.92 0.000
CHRNA6 3 1.00 0.32 0.003 −0.90 0.56 −0.002
chr8p114 15 0.16 0.78 0.004 0.15 0.74 0.004
CHRNA7 4 −0.22 0.97 −0.006 −26.88 0.92 −0.073
CHRNA5 15 0.12 0.82 0.003 0.11 0.74 0.003
CHRNA3 33 −0.06 0.95 −0.001 0.22 0.71 0.006
CHRNB4 15 0.72 0.52 0.002 0.16 0.78 0.004
chr15q25.15 63 0.08 0.90 0.002 0.07 0.83 0.002
CHRNB1 25 1.81 0.18 0.005 2.24 0.11 0.006
CHRNA4 31 0.69 0.53 0.002 20.67 0.18 0.050
1

Multivariate distance-based matrix regression (MDMR);

2

Post-hoc MDMR test performed with common variants only;

3

Post-hoc MDMR test performed with rare variants only;

4

Analysis of CHRNB3 and CHRNA6 variants together;

5

Analysis of CHRNA5, CHRNA3 and CHRNB4 variants together.