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Alignment of probes with the 81-bp core sequence of the rpoB gene. The rpoB gene of M. tuberculosis has an 81-bp core sequence (including codons 508 to 534) that harbors the majority of the mutations clinically relevant for reported drug-resistant TB cases. A 128-bp fragment containing this core region was amplified using bpHDA technology as described above. Probes hybridize to the indicated regions of the amplicon.
