Table 2.

Performance of the HIV DNA PCR, CAP/CTM, and Aptima assays in identifying in utero- and intrapartum-infected and HIV-uninfected infants in the first 6 weeks of life^a

Infection status and time of visit	HIV DNA PCR				CAP/CTM				Aptima
Infected	Total no. of infants testedb	No. with true-positive result	% Sensitivity (95% CI)	PPV (%)	Total no. of infants tested	No. with true-positive result	% Sensitivity (95% CI)	PPV (%)	Total no. of infants tested	No. with true-positive result	% Sensitivity (95% CI)	PPV (%)
Birth	38	26	68.4 (52.5–80.9)	100	38	29	76.3 (60.8–87.0)	100	38	29	76.3 (60.8–87.0)	93.5
2 wk	251	16	64.0 (44.5–79.8)	84.2	253	15	60.0 (40.7–76.6)	100	252	16	64.0 (44.5–79.8)	100
4 wk	24	21	87.5 (69.0–95.7)	91.3	25	24c	96.0 (80.5–99.3)	100	25	24c	96.0 (80.5–99.3)	100
6 wk	22	22	100 (85.1–100)	91.7	24	24	100 (86.2–100)	100	24	24	100 (86.2–100)	96.0
Uninfected	Total no. of infants testedd	No. with true-negative result	% Specificity (95% CI)	NPV (%)	Total no. of infants tested	No. with true-negative result	% Specificity (95% CI)	NPV (%)	Total no. of infants tested	No. with true-negative result	% Specificity (95% CI)	NPV (%)
Birth	67	67	100 (94.6–100)	84.8	69	69	100 (94.7–100)	88.5	106	104	98.1 (93.4–99.5)	92.0
2 wk	60	57	95.0 (86.3–98.3)	86.4	61	61	100 (94.1–100)	85.9	61	61	100 (94.1–100)	87.1
4 wk	62	60	96.8 (89.0–99.1)	95.2	63	63	100 (94.3–100)	98.4	63	63	100 (94.3–100)	98.4
6 wk	61	59	96.7 (88.8–99.1)	100	60	60	100 (94.0–100)	100	61	60	98.4 (91.3–99.7)	100

^aSuperscripts denote numbers of HIV-infected infants with positive tests at birth but negative 2-week results. CI, confidence interval; NPV, negative predictive value; PPV, positive predictive value.

^bExcluding 3 equivocal tests (n = 1 at 4 weeks and n = 2 at 6 weeks).

^cSame IP-infected infant missed by CAP/CTM and Aptima assays at 4 weeks.

^dExcluding 4 equivocal tests (n = 2 at birth, n = 1 at 2 weeks, and n = 1 at 4 weeks).