Fig 2.

Longitudinal analysis of HCV quasispecies structure in the study subject and her mother. Each color represents an identical HCV HVR1 variant in longitudinal analysis. A total of 261 sequences were analyzed as described in the text. M, mother, n = 47; T1, 1.53 years, n = 18; T2, 3.61 years, n = 41; T3, 9.25 years, n = 17; T4, 9.42 years, n = 50; T5, 9.91 years, n = 42; T6, 10.3 years, n = 46. (A) Analysis of the variant profile based on HVR1 nucleic acid sequences. (B) Analysis of the variant profile based on HVR1 amino acid sequences. Arrows indicate the beginning and end of PEGylated interferon alpha-2b and ribavirin treatment. (C) Phylogenetic analysis of HVR1 nucleic acid sequences. The TV-356-79 reference sequence (GenBank accession no. AY385797 [4]) was used as the outgroup.