Table 4.
Nucleotide and amino acid changes found in complete sequencing of target genes
| Gene (no. of resistant isolates tested) | Isolatea | Mutationb |
|
|---|---|---|---|
| Nucleotide (codon)c | Amino acid | ||
| rpoB (5) | JX015 | A2672C (AAG891ACG)* | K972Td* |
| katG (23) | JX044 | C329T (GCC110GTC) | A110V |
| JX084 | C insertion at position 133 | Frameshift | |
| G1388T (CGG463CTG) | R463L | ||
| JX085 | A2084G (GAC695GGC)* | D695G* | |
| G1388T (CGG463CTG) | R463L | ||
| JX099 | T1637C (CTC546CCC)* | L546P* | |
| G1388T (CGG463CTG) | R463L | ||
| JX110 | A141C (GTA47GTC) | V47V | |
| G1388T (CGG463CTG) | R463L | ||
| gyrA (7) | JX001 | G2003A (GGC668GAC) | G668D |
| JX002 | G2003A (GGC668GAC) | G668D | |
| JX003 | G2003A (GGC668GAC) | G668D | |
| JX008 | G2003A (GGC668GAC) | G668D | |
| JX018 | G2003A (GGC668GAC) | G668D | |
| JX064 | G2003A (GGC668GAC) | G668D | |
| gyrB (37) | None | None | |
| rrs (4) | None | None | |
a
JX, isolates from Jiangxi province. The numbers indicate the strain identification.
b
*, Mutation not previously reported. None, no mutation.
c
The mutation coordinates are based on the start nucleotide (codon) of the target genes.
d
The mutation coordinate is in reference to E. coli and not M. tuberculosis.