Table 5.
Most frequently identified mutations within six M. tuberculosis drug resistance-associated loci among isolates resistant to that antibiotic for which each locus serves as a resistance marker
| Drug(s) | Locus | Mutation | Frequency (no. of isolates) | Relative frequencya (%) |
|---|---|---|---|---|
| RIF | rpoB | Ser531Leu | 34 | 44.2 |
| His526Asp | 7 | 9.1 | ||
| Asp516Val | 4 | 5.2 | ||
| INH | katG | Ser315Thr | 43 | 55.8 |
| inhA | –15C→T | 9 | 11.7 | |
| –8T→C | 3 | 3.9 | ||
| OFX | gyrA | Asp94Gly | 19 | 48.7 |
| Asp94Asn | 5 | 12.8 | ||
| Ala90Val | 3 | 7.7 | ||
| gyrB | Asp500His | 1 | 2.6 | |
| Glu540Asp | 1 | 2.6 | ||
| KAN/AMK/CAP | rrs | A1401G | 14 | 73.7 |
a
Compared to the total number of isolates resistant to the drug of interest.