Table 6.
Number of clinical M. tuberculosis isolates stratified by resistance to antibiotics, mutation, and validity valuesa
| Drug | Locus | No. of isolates |
Accuracy values |
||||
|---|---|---|---|---|---|---|---|
| Resistant |
Susceptible |
||||||
| With mutation | Without mutation | With mutation | Without mutation | Sensitivity (%) | Specificity (%) | ||
| RIF | rpoB | 73 | 4 | 0 | 20 | 94.8 | 100 |
| INH | katG | 58 | 19 | 0 | 20 | 75.3 | 100 |
| inhA | 13 | 64 | 0 | 20 | 16.9 | 100 | |
| katG and inhA | 62 | 15 | 0 | 20 | 80.5 | 100 | |
| OFX | gyrA | 32 | 7 | 0 | 20 | 82.1 | 100 |
| gyrB | 2 | 37 | 0 | 20 | 5.1 | 100 | |
| gyrA and gyrB | 33 | 6 | 0 | 20 | 84.6 | 100 | |
| KAN, AMK, and CAP | rrs | 15 | 4 | 0 | 20 | 78.9 | 100 |
| MDR (RIF and INH) | rpoB, katG, and/or inhA | 60 | 17 | 0 | 20 | 77.9 | 100 |
a
The diagnostic performance of the DNA sequencing method in comparison to the drug susceptibility was determined after the resolution of natural polymorphisms and silent mutations.