Table 1. Enzymes and regulators for PI3P metabolism in Saccharomyces cerevisiae and Homo sapiens, and their homologs in Arabidopsis.
| |
S. cerevisiae |
H. sapiens |
Arabidopsis |
|||
|---|---|---|---|---|---|---|
| Protein | Gene ID* | Physiological functions | References | |||
| PtdIns3K complex |
VPS34 |
hVPS34 |
AtVPS34 |
AT1G60490 |
Pollen development and germination |
5, 7, 8, 61 |
| |
VPS15 |
hVPS15 |
AtVPS15 |
AT4G29380 |
Pollen development and germination |
11 |
| |
VPS30/ATG6 |
BECLIN 1 |
AtBECLIN/AtATG6/AtVPS30 |
AT3G61710 |
Pollen germination |
24, 25, 26 |
| |
ATG14 |
hATG14 |
AtATG14 |
AT2G32760 |
ND |
|
| |
VPS38 |
UVRAG |
|
|
|
|
| FAB1/PIKfyve complex |
FAB1 |
PIKfyve |
AtFAB1A AtFAB1B |
AT4G33240 AT3G14270 |
Pollen development |
43, 44 |
| |
VAC14 |
hVAC14 |
AtVAC14 |
AT2G01690 |
ND |
62 |
| |
ATG18 |
hATG18/ WIPI |
AtATG18A AtATG18B AtATG18C AtATG18D AtATG18E AtATG18F AtATG18G AtATG18H |
AT3G62770 AT4G30510 AT2G40810 AT3G56440 AT5G05150 AT5G54730 AT1G03380 AT1G54710 |
Nutrient stress and senescence |
63 |
| |
FIG4 |
|
|
|
|
|
| |
VAC7 |
ND |
ND |
|
|
|
| PtdIns3P 3-phosphatases |
YMR1 |
MTMs MTMRs |
ATMTM1 ATMTM2 |
AT3G10550 AT5G04540 |
Dehydration stress |
32, 64 |
| |
TEP1 CDC14 |
hPTEN/MMAC1 |
AtPTEN1 AtPTEN2A AtPTEN2B |
AT5G39400 AT3G19420 AT3G50110 |
Pollen development and pollen tube growth |
12, 36, 37 |
| PtdIns(3,5)P2 5-phosphatases and regulator |
FIG4 SAC1 SJL1 SJL2 SJL3 |
hSAC1 hSAC2 hSAC3 Synaptojanin1 Synaptojanin2 |
AtSAC1 AtSAC2 AtSAC3 AtSAC4 AtSAC5 AtSAC6 AtSAC7 AtSAC8 AtSAC9 |
At1G22620 At3G14205 At3G43220 At5G20840 At1G17340 At5G66020 At3G51460 At3G51830 At3G59770 |
Pollen development; Cell wall thickening; Root hair development; Stress response |
49, 54, 55, 56, 57, 58 |
| VAC14 | hVAC14 | AtVAC14 | AT2G01690 | ND | 62 | |
*
The bold gene ID indicating the gene has high expression in pollen according to bar.utoronto.ca/efp/cgi-bin/efpWeb.cgi. ND, not determined.