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. 2012 Apr 12;9(74):2365–2382. doi: 10.1098/rsif.2012.0080

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This journal is © 2012 The Royal Society

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 9. — Simulations generated by the optimal fits of the 3-loop Arabidopsis model to experimental data. (a) Experimental expression profiles for the genes CCA1, TOC1, GI and PRR9 in free-running conditions (LL). Expression levels were determined using LUC reporter gene imaging constructs and have been normalized to lie between 0 and 1. (b) The equivalent Boolean time series generated by the logic configuration G_OPT yielding the best fit to data. (c) Boolean expression profiles for the highest-ranked configuration G_DE incorporating the central LHY–CCA1 negative feedback loop of the DE model. In all plots, different components are slightly offset from one another so they can be distinguished more easily. The time step used for solving the logic model was 1.5 h, equal to the data sampling interval.