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. 2012 Jan 5;15(7):1003–1014. doi: 10.1017/S1461145711001738

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© CINP 2012 The online version of this article is published within an Open Access environment subject to the conditions of the Creative Commons Attribution-NonCommercial-ShareAlike licence <http://creativecommons.org/licenses/by-nc-sa/2.5/>. The written permission of Cambridge University Press must be obtained for commercial re-use.

The online version of this article is published within an Open Access environment subject to the conditions of the Creative Commons Attribution-NonCommercial-ShareAlike licence <http://creativecommons.org/licenses/by-nc-sa/2.5/>. The written permission of Cambridge University Press must be obtained for commercial re-use.

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Fig. 2 — Placebo effect in acute schizophrenia trials over time. The mean change from baseline in total Positive and Negative Syndrome Scale (PANSS) scores for subjects receiving placebo across randomized, double-blind, placebo-controlled, clinical trials has increased in the direction of greater improvements that is correlated to the year that the studies were conducted. (Adapted from Kemp et al. 2008.)