Figure 3.

Model of DC-mediated transinfection of CD4⁺ T cells. (A) DCs capture and concentrate virions in trypsin-resistant surface-accessible compartments. (B) CD4⁺ T cells, containing membrane protrusions, bind DCs. (C) The CD4⁺ T-cell protrusions invade the virus-containing compartments and efficiently bind HIV. (D) Virus then migrates toward the cell body to initiate infection. (Figure reproduced from Felts et al. 2010; reprinted, with permission, from Proceedings of the National Academy of Sciences © 2010.)