Figure 10.

Representative TEM images showing the uptake of FePt NPs with different components and surface coatings by human neuroglioma H4 cells at the exposed dose of 25 μg/mL after 24 hours’ incubation.

Notes: (A) Fe₆₀Pt₄₀-OA/OA; (B) Fe₄₅Pt₅₅-OA/OA; (C) Fe₂₇Pt₇₃-OA/OA; (D) Fe₆₀Pt₄₀- Cys; (E) Fe₂₄Pt₇₆-Cys. The release and diffusion of FePt NPs from the vesicles into the cytoplasm were observed and are marked with white arrows in panels (A and B).

Abbreviations: TEM, transmission electron microscopy; NPs, nanoparticles; OA/OA, oleic acid/oleylamine; Cys, cysteine.