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. Author manuscript; available in PMC: 2012 Jul 26.
Published in final edited form as: Stem Cells. 2010 Nov;28(11):2088–2098. doi: 10.1002/stem.532

Figure 4. Pathway-focused PCR array analysis of the gene expression of ECM and adhesion molecules in cells cultured as cardiospheres or monolayers.

Figure 4

A) The scatter plot demonstrates that 12 of the 84 ECM and adhesion genes are up-regulated (red circles) in cardiospheres relative to monolayer cells. B) The names and fold changes of genes that are up- or down-regulated more than 4-fold in cardiosphere culture compared with monolayer culture. Furthermore, qRT-PCR analysis of 5 separate RNA samples from different human cardiac outgrowth cells confirmed that the mRNA expression of IGTA2 (C), LAMB1 (D), and MMP3 (E) is increased in cells cultured as cardiospheres when compared with monolayer cells.

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