Figure 6. Cardiac function after treatment and their relationship to cell engraftment.
A) LVEF at baseline and 1 and 3 weeks after treatments. B) Percentage change in LVEF from baseline levels 3 weeks after cell injection. (Control group: saline injection only; Mono group: injection with monolayer-cultured CDCs; 2nd-CSp group: injection with cardiospheres reformed from twice-passaged CDCs; Pri-CSp group: injection with cardiospheres primarily formed from cardiac-derived cells; Diss-CSp group: injection with cells dissociated from secondary cardiospheres). The percentage of area of engrafted human cardiac-derived cells within the infarcted heart of mice is strongly correlated with either the absolute values of LVEF (C) or the relative LVEF changes to baseline (D), 3 weeks after treatments.