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. 2012 Jul 26;8(7):e1002799. doi: 10.1371/journal.pgen.1002799

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Chelysheva et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A: Multiple sequence alignment of HEI10 proteins from plants (green bar, At- Arabidopsis thaliana, Gm- Glycine max, Os- Oryza sativa, Pp- Physcomitrella patens, Zm- Zea mays), amoeba (Dd- Dictyostelium discoideum), fungi (Pm- Penicillium marneffei), nematodes (Ts- Trichinella spiralis), insects (Aa- Aedes aegypti) and vertebrates (Dr- Danio rerio, Hs- Homo sapiens, Mm- Mus musculus, Xt- Xenopus tropicalis) showing the conserved N-terminal region including the RING finger (boxed in black) and the coiled-coil forming segment (boxed in red). Protein sequences are listed with a 2-letter species code followed by the reference to the sequence source, numbers indicate amino acid positions. The alignment was generated using muscle and visualized with Clustal [87]. B: BLAST similarity network of HEI10 and Zip3 proteins. The BLAST relationship of all Zip3 and HEI10 homologous proteins from a selected set of species is shown. The nodes represent all Zip3-like (upper panel) and HEI10-like (lower panel) sequences for the predetermined set of species. The edges illustrate their BLAST similarity, where increasing edge width and darker edge colour indicates higher similarity (lower BLAST E-value). The highlighted nodes show the following sequences: mammalian (Cl- Canis lupus: XP_539671 HEI10, XP_855088 RNF212, XP_549701 C14orf164, Hs-Homo sapiens: NP_878269 HEI10, NP_919420 RNF212, XP_003119614 C14orf164, Mm-Mus muscuslus: NP_001104589 HEI10, D3Z423 C14orf64, Rn- Rattus norvegicus: XP_002728107 Rnf212), fungi (Nd- Naumovozyma dairenensis: CCD27121, Kl- Kluyveromyces lactis: XP_451682, Sc- Saccharomyces cerevisiae: NP_013498 Cst9 = Zip3, Pm- Penicillium marneffei: XP_002145282), plants (At- Arabidopsis thaliana: NP_175754 AT1G53490, Os- Oryza sativa: NP_001046371, Pp- Physcomitrella patens: XP_001769363, Zm- Zea mays: NP_001152027) and nematode (Ce- Caenorhabditis elegans: NP_492311 ZHP-3). Among these, ScZip3 [24], CeZHP-3 [88], MmHEI10 (MEI4, [39]), AtHEI10 (this study) and HsRNF212 [71] have been shown to be involved in meiotic recombination. Other species code: Aa- Aedes aegypti, Ac- Angiostrongylus cantonensis, Bf- Branchiostoma floridae, Ce- Caenorhabditis elegans, Ci- Ciona intestinalis, Dr- Danio rerio, Dd- Dictyostelium discoideum, Eh- Entamoeba histolytica, Ph- Pediculus humanus, Ts- Trichinella spiralis, Xt- Xenopus tropicalis.