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. 2012 Jul 26;8(7):e1002841. doi: 10.1371/journal.pgen.1002841

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Kutter et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Normalised nucleotide substitution rates for (A) 160 intergenic lncRNA loci conserved in rodents (expressed in Mmus, Mcas and Rnor) and 108 Mus genus specific intergenic lncRNA loci; and (B) 159 putative intergenic lncRNA promoters conserved in rodents and 104 Mus genus specific intergenic lncRNA putative promoters. Putative proximal intergenic lncRNA promoters were defined as the 400 bp upstream region of the predicted TSS. Yellow dashed line represents the expected neutral substitution rate. Compared to neutral sequence (ancestral repeats, AR) in the vicinity, nucleotide substitution rates differ significantly for loci and promoter of intergenic lncRNA transcripts conserved in rodents (as indicated by asterisks ***, p<0.001) and the promoters of Mus genus specific intergenic lncRNAs (***, p<0.001).