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. 2012 Jul 26;7(7):e41272. doi: 10.1371/journal.pone.0041272

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© 2012 Torbensen et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

Extracellular amino acids induce the SPS complex at the plasma membrane (PM) and the activated complex elicits gene expression of amino acid transporters DIP5 and GNP1. Dip5 and Gnp1 activate FLO11 transcription in a manner dependent on activity of the PKA-pathway (A). Inactive SPS signaling indirectly leads to increased transcript levels of GAP1. Gap1 increases the amino acid pool concentration, which in turn triggers a PKA independent signal for induction of FLO genes (B). PM, plasma membrane. NM, nuclear membrane.