Table 2. MHC-II binding results for the identified four peptide segments.
PeptideSegmentNumber | Allele | Position | Sequence | arb_core | arb_score | arb_percentile | smm_core | smm_score | smm_percentile | Consensuspercentile |
A | HLA DPA1*01-DPB1*0401 | 1∶193–207 | VKVCPLNTQALGIGC | VKVCPLNTQ | 4620.916471 | 39.42 | LNTQALGIG | 14895 | 80.96 | 60.19 |
HLA DPA1*01-DPB1*0401 | 1∶194–208 | KVCPLNTQALGIGCQ | PLNTQALGI | 7408.864636 | 57.03 | LNTQALGIG | 16291 | 83.41 | 70.22 | |
B | HLA DPA1*01-DPB1*0401 | 1∶241–255 | TTTCTIRNCKKLGPR | RNCKKLGPR | 55554.40475 | 99.04 | IRNCKKLGP | 35395 | 96.59 | 97.815 |
HLA DPA1*01-DPB1*0401 | 1∶242–256 | TTCTIRNCKKLGPRE | NCKKLGPRE | 19175.64294 | 87.39 | IRNCKKLGP | 35871 | 96.7 | 92.045 | |
C | HLA DPA1*01-DPB1*0401 | 1∶272–286 | TADPTTNPQIERMMR | TADPTTNPQ | 5420.43634 | 45.2 | TTNPQIERM | 25803 | 92.94 | 69.07 |
HLA DPA1*01-DPB1*0401 | 1∶273–287 | ADPTTNPQIERMMRV | ADPTTNPQI | 5654.176164 | 46.76 | TTNPQIERM | 18235 | 86.23 | 66.495 | |
D | HLA DPA1*01-DPB1*0401 | 1∶300–314 | VDYINQIVQVMSKRS | VDYINQIVQ | 4015.810591 | 34.58 | INQIVQVMS | 6833 | 53.94 | 44.26 |
HLA DPA1*01-DPB1*0401 | 1∶301–315 | DYINQIVQVMSKRSR | DYINQIVQV | 7495.055799 | 57.47 | INQIVQVMS | 8788 | 63.44 | 60.455 |
Results of the peptide-a, b, c and d submitted to the IEDB T-cell MHC-II binding prediction server are tabulated here. For each peptide the server generates two overlapping peptides; the peptides for the four groups are shown in different colors.