Table 2. Distribution of CTLA-4 genotype among patients and controls included in the meta-analysis.
Studies | Asthma | Control | HWE | ||||
11a | 12b | 22c | 11 | 12 | 22 | (P value) | |
+49 A/G | |||||||
Nakao | 27 | 52 | 41 | 32 | 107 | 61 | 0.189 |
Hizawa | 40 | 178 | 121 | 40 | 140 | 125 | 0.935 |
Howard | 76 | 82 | 19 | 39 | 72 | 23 | 0.297 |
Lee | 15 | 24 | 49 | 8 | 29 | 49 | 0.238 |
Schubert | 98 | 105 | 28 | 105 | 127 | 38 | 0.968 |
Jasek | 66 | 101 | 52 | 33 | 48 | 21 | 0.645 |
Sohn | 45 | 125 | 156 | 19 | 103 | 132 | 0.859 |
Chan | 40 | 119 | 113 | 21 | 75 | 75 | 0.737 |
Daley | 238 | 290 | 88 | 291 | 338 | 98 | 0.992 |
Oh | 61 | 312 | 369 | 16 | 107 | 115 | 0.178 |
Undarmaa 1 | 49 | 153 | 123 | 43 | 155 | 138 | 0.959 |
Undarmaa 2 | 58 | 175 | 134 | 106 | 323 | 247 | 0.981 |
−318 C/T | |||||||
Nakao | 97 | 19 | 4 | 157 | 43 | 0 | 0.088 |
Hizawa | 265 | 71 | 3 | 238 | 65 | 2 | 0.278 |
Howard | 144 | 30 | 2 | 115 | 14 | 2 | 0.059 |
Lee | 70 | 16 | 2 | 67 | 15 | 4 | 0.022 |
Jasek | 172 | 44 | 3 | 79 | 22 | 1 | 0.694 |
Schubert | 181 | 47 | 3 | 214 | 53 | 3 | 0.889 |
Qian | 75 | 13 | 2 | 84 | 15 | 1 | 0.721 |
Sohn | 247 | 77 | 2 | 199 | 54 | 1 | 0.182 |
Daley | 537 | 100 | 5 | 616 | 128 | 7 | 0.902 |
Undarmaa 1 | 253 | 67 | 5 | 263 | 68 | 5 | 0.801 |
Undarmaa 2 | 284 | 78 | 5 | 512 | 153 | 11 | 0.911 |
DeWan | 58 | 7 | 1 | 35 | 6 | 1 | 0.267 |
Anantharaman | 350 | 128 | 12 | 343 | 134 | 13 | 0.799 |
−1147 C/T | |||||||
Howard | 108 | 46 | 2 | 97 | 18 | 2 | 0.295 |
Jasek | 146 | 65 | 8 | 66 | 31 | 5 | 0.587 |
Chan | 216 | 68 | 7 | 129 | 43 | 3 | 0.787 |
Daley | 445 | 181 | 18 | 500 | 226 | 25 | 0.931 |
DeWan | 52 | 13 | 1 | 29 | 12 | 1 | 0.853 |
Anantharaman | 335 | 140 | 15 | 307 | 162 | 21 | 0.949 |
CT60 A/G | |||||||
Chan | 13 | 97 | 183 | 6 | 58 | 109 | 0.611 |
Berce | 14 | 62 | 26 | 21 | 34 | 29 | 0.093 |
Daley | 191 | 317 | 132 | 229 | 369 | 148 | 0.977 |
DeWan | 8 | 31 | 27 | 4 | 19 | 19 | 0.810 |
Anantharaman | 36 | 193 | 261 | 21 | 161 | 308 | 0.994 |
−1722 C/T | |||||||
Daley | 551 | 89 | 4 | 644 | 102 | 4 | 0.986 |
Sleiman | 663 | 127 | 6 | 1666 | 308 | 14 | 0.954 |
Noguchi | 340 | 463 | 135 | 862 | 1131 | 391 | 0.537 |
rs926169 A/C | |||||||
Daley | 236 | 307 | 100 | 282 | 356 | 111 | 0.937 |
Sleiman | 284 | 382 | 127 | 743 | 945 | 300 | 0.987 |
Noguchi | 135 | 455 | 342 | 336 | 1110 | 938 | 0.793 |
AA or CC;
AG, CT, or AC;
GG, TT or CC.
HWE, Hardy-Weinberg equilibrium.