Table 3. Determination of the genetic effects of CTLA-4 polymorphisms on asthma and sensitivity analyses.
| Polymorphisms | Study | Sample size | No. of | Test of association | Model | Heterogeneity | |||||
| case | control | studies | OR (95% CI) | Z | P Value | χ 2 | P Value | I 2 (%) | |||
| +49 A/G | |||||||||||
| AA vs. GG | Overall | 2108 | 1875 | 12 | 1.18 (1.00–1.40) | 1.98 | 0.05 | R | 12.78 | 0.31 | 14.0 |
| AG vs. GG | Overall | 3008 | 2746 | 12 | 1.02 (0.91–1.14) | 0.34 | 0.74 | R | 6.58 | 0.83 | 0.0 |
| AA vs. AG | Overall | 2529 | 2377 | 12 | 1.16 (0.99–1.36) | 1.89 | 0.06 | R | 14.76 | 0.19 | 25.0 |
| AA vs. AG+GG | Overall | 3822 | 3499 | 12 | 1.18 (1.01–1.37) | 2.07 | 0.04 | R | 15.42 | 0.16 | 29.0 |
| AA vs. AG+GG | Asian | 2579 | 2266 | 8 | 1.21 (1.01–1.46) | 2.01 | 0.04 | R | 7.52 | 0.38 | 7.0 |
| AA vs. AG+GG | Caucasian | 1243 | 1233 | 4 | 1.12 (0.85–1.48) | 0.83 | 0.41 | R | 6.77 | 0.08 | 56.0 |
| AA vs. AG+GG | Atopic | 1954 | 1892 | 7 | 1.26 (1.00–1.59) | 1.94 | 0.05 | R | 8.30 | 0.22 | 28.0 |
| −318 C/T | |||||||||||
| CC vs. TT | Overall | 2710 | 2903 | 12 | 0.99 (0.65–1.51) | 0.04 | 0.97 | R | 4.62 | 0.95 | 0.0 |
| CT vs. TT | Overall | 699 | 798 | 12 | 0.99 (0.64–1.52) | 0.04 | 0.97 | R | 5.90 | 0.88 | 0.0 |
| CC vs. CT | Overall | 3344 | 3610 | 12 | 1.03 (0.92–1.16) | 0.52 | 0.61 | R | 5.38 | 0.91 | 0.0 |
| CC+CT vs. TT | Overall | 3391 | 3657 | 12 | 0.96 (0.63–1.47) | 0.18 | 0.86 | R | 4.64 | 0.95 | 0.0 |
| CC+CT vs. TT | HWE | 3479 | 3743 | 13 | 1.01 (0.67–1.52) | 0.03 | 0.98 | R | 5.38 | 0.94 | 0.0 |
| CC+CT vs. TT | Asian | 2057 | 2361 | 7 | 0.91 (0.55–1.51) | 0.36 | 0.72 | R | 4.16 | 0.66 | 0.0 |
| CC+CT vs. TT | Caucasian | 1268 | 1254 | 4 | 1.06 (0.48–2.34) | 0.14 | 0.89 | R | 0.29 | 0.96 | 0.0 |
| CC+CT vs. TT | Atopic | 1793 | 2058 | 6 | 0.97 (0.57–1.65) | 0.11 | 0.91 | R | 3.70 | 0.59 | 0.0 |
| −1147 C/T | |||||||||||
| CC vs. TT | Overall | 1353 | 1185 | 6 | 1.29 (0.87–1.91) | 1.26 | 0.21 | R | 1.05 | 0.96 | 0.0 |
| CT vs. TT | Overall | 564 | 549 | 6 | 1.16 (0.77–1.73) | 0.70 | 0.48 | R | 1.21 | 0.94 | 0.0 |
| CC vs. CT | Overall | 1815 | 1620 | 6 | 1.04 (0.81–1.34) | 0.31 | 0.75 | R | 10.67 | 0.06 | 53.0 |
| CT60 A/G | |||||||||||
| AA vs. GG | Overall | 891 | 894 | 5 | 1.18 (0.80–1.74) | 0.82 | 0.41 | R | 6.63 | 0.16 | 40.0 |
| AG vs. GG | Overall | 1329 | 1254 | 5 | 1.20 (0.94–1.52) | 1.45 | 0.15 | R | 7.01 | 0.14 | 43.0 |
| AA vs. AG | Overall | 962 | 922 | 5 | 0.95 (0.63–1.45) | 0.23 | 0.82 | R | 7.95 | 0.09 | 50.0 |
| AA+AG vs. GG | Overall | 1591 | 1535 | 5 | 1.19 (0.94–1.49) | 1.47 | 0.14 | R | 6.86 | 0.14 | 42.0 |
| −1722 C/T | |||||||||||
| CC vs. TT | Overall | 1699 | 3581 | 3 | 1.12 (0.90–1.40) | 1.01 | 0.31 | R | 0.32 | 0.85 | 0.0 |
| CT vs. TT | Overall | 824 | 1950 | 3 | 1.17 (0.94–1.45) | 1.39 | 0.16 | R | 0.33 | 0.85 | 0.0 |
| CC vs. CT | Overall | 2233 | 4713 | 3 | 0.97 (0.86–1.09) | 0.54 | 0.59 | R | 0.01 | 0.99 | 0.0 |
| CC+CT vs. TT | Overall | 2378 | 5122 | 3 | 1.15 (0.93–1.41) | 1.32 | 0.19 | R | 0.37 | 0.83 | 0.0 |
| rs926169 | |||||||||||
| AA vs. CC | Overall | 1244 | 2710 | 3 | 0.99 (0.85–1.15) | 0.18 | 0.86 | R | 1.48 | 0.48 | 0.0 |
| AC vs. CC | Overall | 1713 | 3760 | 3 | 1.05 (0.93–1.19) | 0.74 | 0.46 | R | 1.61 | 0.45 | 0.0 |
| AA vs. AC | Overall | 1799 | 3772 | 3 | 0.96 (0.85–1.09) | 0.63 | 0.53 | R | 0.07 | 0.97 | 0.0 |
| AA+AC vs. CC | Overall | 2368 | 5121 | 3 | 1.03 (0.91–1.17) | 0.50 | 0.61 | R | 2.15 | 0.34 | 7.0 |
vs., versus; R, random-effects model.