Figure 1. MRSA infection induces lower KC and PMNs at the infection site in aged mice.

Age- and gender- matched mice were infected subcutaneously (s.c.) with 10⁹ CFUs of CST9. On day 3 post-infection, the mice were sacrificed, and (A) skin lesion size, (B) skin CFUs, and (C) kidney CFUs were determined. (D) MIP-2, (E) KC, and (F) PMNs from the lesions were quantitated at 3 hours post-infection. At least 3 mice were infected for each time point for IVIS analysis. At least 3 mice in each age group were infected for the chemokine, cytokine, and PMN analyses. *p<0.05, **p<0.01 for comparisons of young and aged mice.