Table 4. Candidate gene analysis of two SNPs in the candidate gene CDH2.
| Breed | SNP a | Case | Control | MAF | P | OR |
| All breeds | 1164 | A(0.44) | 0.886 | |||
| 1144 (T/T) | 58 (0.54) | 49 (0.46) | C(0.16) | 1 | 0.97 | |
| BTb | 1164 | A(0.14) | 0.283 | |||
| 1144 (T/T) | 40 (0.59) | 28 (0.41) | C(0.04) | 0.642 | 0.36 | |
| GS | 1164 | C(0.22) | 0.565 | |||
| 1144 (T/T) | 11 (0.41) | 16 (0.59) | C(0.29) | 1 | 0.96 | |
| SBT | 1164 | G(0.33) | 1 | |||
| 1144 (T/T) | 7 (0.58) | 5 (0.42) | C(0.35) | 0.667 | 0.54 |
a
Two SNPs were selected for analysis: 1) 1144 (63,867,472) as the T/T genotype for this SNP was previously associated with Doberman compulsive behaviour [22], and 2) 1164 (63,867,492) a nearby SNP which was included as it had more variation in all of the breeds. For 1144 the frequencies for genotype T/T (for cases and controls). minor allele frequencies (MAF) and odds ratio (OR) are presented. For 1164 minor allele frequencies (MAF) and the P value for SNP association is presented. All P values are calculated using Fisher’s Exact test.
b
Bull Terrier includes both miniature and standard forms.