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. 2012 Jul 26;7(7):e41625. doi: 10.1371/journal.pone.0041625

Figure 1. Location of Site A and Site B in the GII-4 NoV P2 domain.

Figure 1

The NoV genome has three open reading frames (ORF1, 2, 3) and the major capsid protein (VP1) is encoded by ORF2. The VP1 protein has three main domains: an N-terminal domain (N), the highly conserved shell domain (S), and the protruding domain (P) which forms surface exposed spikes on the virus surface, which is further subdivided into hypervariable P2 domain (P2) and the more conserved P1 domain (P1). Previously, we identified two antigenic sites in the hypervariable P2 domain of the GII-4 NoV capsid protein [15]. Site A (shown in red) is comprised of consecutive amino acid residues 296–298. Site B (shown in blue) is comprised of continuous amino acid residues 393–395. Amino acid position numbering relative to prototype strain Lordsdale/1993/UK (Accession Number: X86557), residues mapped onto the surface of GII-4 NoV strain VA387 P-domain crystal structure (PDB Number 2OBS) described by Cao et al [22].