Table 3. Stratification analysis for associations between ERCC5 variant genotypes and ESCC risk.
Variables | rs2296147 (cases/controls) | Adjusted ORa (95% CI) | P a | rs2094258 (cases/controls) | Adjusted ORa (95% CI) | P a | rs873601 (cases/controls) | Adjusted ORa (95% CI) | P a | |||
TT | CT/CC | CC | TT/CT | GG | AG/AA | |||||||
Age, yr | ||||||||||||
≤60 (median) | 361/344 | 193/213 | 0.87 (0.67–1.13) | 0.31 | 211/221 | 343/336 | 1.06 (0.82–1.37) | 0.71 | 149/147 | 405/410 | 1.06 (0.80–1.41) | 0.92 |
>60 (median) | 396/355 | 165/205 | 0.75 (0.57–0.97) | 203/203 | 358/357 | 0.98 (0.76–1.26) | 165/164 | 396/396 | 0.95 (0.72–1.24) | |||
Sex | ||||||||||||
Males | 608/545 | 293/326 | 0.83 (0.68–1.02) | 0.64 | 338/336 | 563/535 | 1.04 (0.85–1.28) | 0.88 | 252/243 | 649/628 | 1.00 (0.81–1.25) | 0.79 |
Females | 149/154 | 65/92 | 0.66 (0.43–1.01) | 76/88 | 138/158 | 1.13 (0.75–1.72) | 62/68 | 152/178 | 0.93 (0.60–1.44) | |||
Smoking status | ||||||||||||
0 | 287/319 | 137/193 | 0.81 (0.61–1.07) | 0.95 | 161/193 | 263/319 | 1.02 (0.77–1.34) | 0.76 | 114/136 | 310/376 | 0.96 (0.71–1.30) | 0.87 |
≤16 (mean) | 110/148 | 41/96 | 0.59 (0.37–0.94) | 56/98 | 95/146 | 1.09 (0.71–1.69) | 48/66 | 103/178 | 0.77 (0.49–1.23) | |||
>16 (mean) | 360/232 | 180/129 | 0.84 (0.62–1.14) | 197/133 | 343/228 | 1.05 (0.78–1.41) | 152/109 | 388/252 | 1.15 (0.83–1.58) | |||
Drinking status | ||||||||||||
Never | 429/469 | 192/284 | 0.75 (0.59–0.95) | 0.38 | 225/288 | 396/465 | 1.10 (0.88–1.38) | 0.49 | 176/197 | 445/556 | 0.88 (0.69–1.13) | 0.16 |
Ever | 328/230 | 166/134 | 0.83 (0.61–1.13) | 189/136 | 305/228 | 0.97 (0.72–1.31) | 138/114 | 356/250 | 1.18 (0.86–1.61) | |||
BMI | ||||||||||||
<24.0 | 434/273 | 199/160 | 0.77 (0.59–1.00) | 0.80 | 226/161 | 407/272 | 1.07 (0.83–1.39) | 0.61 | 172/120 | 461/313 | 1.04 (0.79–1.38) | 0.51 |
≥24.0 | 323/426 | 159/258 | 0.82 (0.64–1.06) | 188/263 | 294/421 | 0.97 (0.76–1.24) | 142/191 | 340/493 | 0.94 (0.73–1.23) |
Obtained in logistic regression models with adjustment for age, sex, BMI, smoking status and drinking status.
P for heterogeneity test using the Chi-square-based Q test.