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. 2012 Jul 26;7(7):e41500. doi: 10.1371/journal.pone.0041500

Table 3. Stratification analysis for associations between ERCC5 variant genotypes and ESCC risk.

Variables	rs2296147 (cases/controls)		Adjusted OR^a (95% CI)	P ^a	rs2094258 (cases/controls)		Adjusted OR^a (95% CI)	P ^a	rs873601 (cases/controls)		Adjusted OR^a (95% CI)	P ^a
	TT	CT/CC			CC	TT/CT			GG	AG/AA
Age, yr
≤60 (median)	361/344	193/213	0.87 (0.67–1.13)	0.31	211/221	343/336	1.06 (0.82–1.37)	0.71	149/147	405/410	1.06 (0.80–1.41)	0.92
>60 (median)	396/355	165/205	0.75 (0.57–0.97)		203/203	358/357	0.98 (0.76–1.26)		165/164	396/396	0.95 (0.72–1.24)
Sex
Males	608/545	293/326	0.83 (0.68–1.02)	0.64	338/336	563/535	1.04 (0.85–1.28)	0.88	252/243	649/628	1.00 (0.81–1.25)	0.79
Females	149/154	65/92	0.66 (0.43–1.01)		76/88	138/158	1.13 (0.75–1.72)		62/68	152/178	0.93 (0.60–1.44)
Smoking status
0	287/319	137/193	0.81 (0.61–1.07)	0.95	161/193	263/319	1.02 (0.77–1.34)	0.76	114/136	310/376	0.96 (0.71–1.30)	0.87
≤16 (mean)	110/148	41/96	0.59 (0.37–0.94)		56/98	95/146	1.09 (0.71–1.69)		48/66	103/178	0.77 (0.49–1.23)
>16 (mean)	360/232	180/129	0.84 (0.62–1.14)		197/133	343/228	1.05 (0.78–1.41)		152/109	388/252	1.15 (0.83–1.58)
Drinking status
Never	429/469	192/284	0.75 (0.59–0.95)	0.38	225/288	396/465	1.10 (0.88–1.38)	0.49	176/197	445/556	0.88 (0.69–1.13)	0.16
Ever	328/230	166/134	0.83 (0.61–1.13)		189/136	305/228	0.97 (0.72–1.31)		138/114	356/250	1.18 (0.86–1.61)
BMI
<24.0	434/273	199/160	0.77 (0.59–1.00)	0.80	226/161	407/272	1.07 (0.83–1.39)	0.61	172/120	461/313	1.04 (0.79–1.38)	0.51
≥24.0	323/426	159/258	0.82 (0.64–1.06)		188/263	294/421	0.97 (0.76–1.24)		142/191	340/493	0.94 (0.73–1.23)

^a

Obtained in logistic regression models with adjustment for age, sex, BMI, smoking status and drinking status.

^b

P for heterogeneity test using the Chi-square-based Q test.