Table 4. EC50s of insulin, IGF1, glargine and glargine metabolites for PIP₃ production, Akt and Erk activation and thymidine incorporation in MCF-7 cells.

	pAkt	pERK1/2	PIP3 MCF-7	[14C]thymidine MCF-7
	EC50 (nM)	EC50 (nM)	EC50 (nM)	EC50 (nM)
Insulin	35.6±7.7	107±28	44.91±8.93	15.94±3.51
Glargine	4.37±1.09 **	24.9±6.6 *	9.33±3.18 *	3.89±0.64 **
M1	42.52±9.29	211±53	307.88±84.36 *	29.30±1.53*
M2	44.54±10.52	170±50	341.12±122.26 *	20.00±1.25
IGF1	0.67±0.26 **	6.7±2.2 **	0.76±0.23 **	0.42±0.04 **

Results are the means ± S.E.M. of 4 to 6 independent experiments.

^{*, **}, p<0.05 or p<0.01 respectively, when compared to insulin.