Table 4. Risk factors for Overall survival of liver transplantation by Multivariate Analysis.

Items	n	Mean±SD (months)	Univariate analysis	Multivariate analysis
Age (yr)			0.192
<47	169	63.21±2.23
≥47	170	59.23±3.41
Gender (M/F)			0.241
Male	251	57.34±2.16
Female	78	59.54±3.31
HBV infeciont			0.105
Present	328	58.94±2.16
Absent	11	62.54±5.31
HCV infection			0.143
Present	22	59.24±2.16
Absent	317	61.54±3.31
ALT			0.267
<135	169	63.52±2.34
≥135	170	58.12±3.64
MELD score			0.228
<18	169	66.21±4.43
≥18	170	62.03±5.22
Liver cirrhosis			0.312
Present	271	55.34±2.16
Absent	68	59.54±3.31
Nodules numbers			0.109
≤3	227	65.52±1.54
>3	62	59.12±2.75
AFP levels			0.001	0.031a
<400	66	73.66±2.09
≥400	273	62.09±1.64
Macrovascular invasion			<0.001	<0.001b
Present	37	40.28±4.16
Absent	302	67.22±2.35
Microvascular invasion			<0.001	0.009c
Present	71	46.56±3.46
Absent	268	69.31±3.45
Pathologic characteristics			0.092
Poor differentiated	106	62.34±1.46
Well differentiated	233	59.86±3.17
Pre-transplant treatment			0.185
Present	164	62.54±3.46
Absent	175	59.91±4.32

^aRelative risk:1.91, 95% CI: 1.04–3.02.

^bRelative risk:3.33, 95% CI: 1.77–6.24.

^cRelative risk:2.93, 95% CI: 1.31–6.11.

Cox Proportional Hazards model showed that vascular invasion, including macrovascular and microvascular invasion, as well as AFP level >400 IU/L were risk factors for tumor recurrence after OLT.