Table 4. Gene expression changes of dTip60^E431Q misregulated target genes in the different transgenic lines.

Gene Namea	Transgenic Fly Line (Relative Fold Change)b
	dTip60E431Q	dTip60WT	APP; dTip60E431Q	APP; dTip60WT
Buffy § ,	1.4	1.6	−1.5	3.5
ALiX	1.4	2.1	1.5	2.3
CalpA § ,	1.5	3.5	−2.1	−1.8
TRAF4 § ,	1.7	3.9	−1.5	−1.7
Frizzled §	2.3	−1.5	−2.1	−1.5
Wingless §	2.4	−1.7	−1.9	−1.5
dMyc §	3.8	−3.2	−2.5	−2.3
PDCD5 §	−4.7	2	1	1.8
Dmel\CG9418	1193.4	14.8139954	824.094897	2472.348951

^aQuantitative RT-PCR analysis was performed for the indicated target genes.

^bStaged second instar larvae ubiquitously expressing the indicated transgene(s) were used for cDNA preparation. Quantitative RT-PCR reactions were carried out in triplicate and the relative fold change was calculated using the 2−ΔΔCT method using RP49 as control.

^§Genes that were differentially regulated between flies expressing the Tip60 HAT mutant dTip60^E431Q alone and in conjunction with APP.

Gene that were differentially regulated between flies overexpressing dTip60^WT alone or together with APP.