. Author manuscript; available in PMC: 2013 Aug 1.

Published in final edited form as: Bioorg Med Chem. 2012 Jun 9;20(15):4744–4750. doi: 10.1016/j.bmc.2012.06.004

Table 3.

Strand damage by C1027 under aerobic conditions in strands containing nucleotides 20–38.^a,^b

Duplex	Tot. Strand Damage (%)	Damage Site(s)	Yield C1027- DNA adduct (%)
1a	95.0 ± 0.3	A₂₉, A₃₀ (1.4:1)	5.2 ± 0.1
1b	46.4 ± 2.5	T₂₈, A₂₉, A₃₀, A₃₃	4.3 ± 0.8
1c	47.2 ± 2.4	G₂₇, T₂₈, A₂₉, A₃₀, A₃₃	7.0 ± 0.7
1d	54.6 ± 3.0	T₂₈, A₂₉, A₃₀, C₃₂, A₃₃	4.7 ± 0.4
1e	63.8 ± 3.8	A₂₉, A₃₀	5.4 ± 0.2
1f	92.4 ± 0.5	A₂₉, A₃₀, G₃₁ (4.0:5.9:1)	11.1 ± 0.8
1g	77.6 ± 0.3	A₂₉, A₃₀, A₃₁ (1:2.4:4.7)	8.1 ± 0.8
1h	96.5 ± 0.8	A₂₉, A₃₀, T₃₁ (3.5:6.8:1)	4.7 ± 0.1

Reactions carried out on 5'-³²P-labeled DNA.

Yields are the average ± std. dev. of 3 individual reactions.