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. Author manuscript; available in PMC: 2013 Aug 1.

Published in final edited form as: Bioorg Med Chem. 2012 Jun 9;20(15):4744–4750. doi: 10.1016/j.bmc.2012.06.004

Table 7.

C1027-DNA interstrand cross-link formation

	Duplex (local sequence)	ICL Yield (%)^a	Nucleotides Cross-linked
1a	5’-G8 T₉ T₁₀ A₁₁-T₁₂ 3’-C₃₁ A₃₀ A₂₉ T₂₈ A₂₇	36.0 ±16.1	A₁₁, ,A₃₀; A_11, A₂₉(~4:1)
1e	5’-G₈ T₉ T₁₀ T₁₁ T₁₂ 3’-C₃₁ A₃₀ A₂₉ A₁₈ A₂₇	19.1^b	T₁₁. A₃₀
1f	5’- C₈ T₉ T₁₀ A₁₁ T₁₂ 3’-G₃₁ A₃₀ A₂₉ T₂₈ A₂₇	57.6 ±0.1	A₁₁, A₃₀
1g	5’-T₈ T₉ T₁₀ A₁₁ T₁₂ 3’-A₃₁ A₃₀ A₂₉ T₂₈ A₂₇	51.9 ±13.0	T₁₀, A₃₁
1h	5’-A₈ T₉ T₁₀ A₁₁ T₁₂ 3’-T₃₁ A₃₀ A₂₉ T₂₉ A₂₇	38.9 ± 7.9	A₁₁ ,A₃₀

^a

Yields are the average of 3 measurements.

^b

Single measurement.