Table 2.
Primary outcomes
| Analysis | Events (studies) | Risk ratio (95% CI) | I2 |
|---|---|---|---|
| Random effects* | |||
| Myocardial infarction | 6598 (10)† | 1.23 (1.15 to 1.31) | 0% |
| All coronary events | 17 359 (28)† | 1.24 (1.10 to 1.39) | 85% |
| Ischaemic stroke | 1854 (2)† | 1.05 (1.01 to 1.09) | 0% |
| Sensitivity analyses‡ | |||
| Myocardial infarction, unadjusted | 4408 (5) | 1.41 (1.17 to 1.70) | 70% |
| Myocardial infarction, adjusted | 4408 (5) | 1.27 (1.10 to 1.45) | 35% |
| Coronary events, unadjusted | 8154 (12) | 1.21 (1.06 to 1.39) | 76% |
| Coronary events, adjusted | 8154 (12) | 1.17 (1.05 to 1.31) | 56% |
| Ischaemic stroke, unadjusted | 1854 (2) | 1.09 (1.04 to 1.14) | 0% |
| Ischaemic stroke, adjusted | 1854 (2) | 1.05 (1.01 to 1.09) | 0% |
| Trim and filled estimates | |||
| Myocardial infarction | (12)§ | 1.22 (1.15 to 1.30) | NA |
| All coronary events | (32)§ | 1.19 (1.06 to 1.34) | NA |
| Ischaemic stroke¶ | — | — | — |
NA=not applicable.
*These analyses preferentially pooled adjusted risk estimates, with unadjusted estimates included only for studies that reported crude estimates alone.
†Random effects mean event risks for myocardial infarction, coronary events, and ischaemic stroke were 0.8%, 2.9%, and 2.1% (totalled over follow-up for cohort studies).
‡These analyses pooled subset of studies that reported both unadjusted and adjusted risk estimates.
§Includes hypothetical unpublished studies imputed to left of mean.
¶Duvall and Tweedie’s trim and fill method could not be applied, as only two studies were reported.