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. Author manuscript; available in PMC: 2013 Aug 1.

Published in final edited form as: Hepatology. 2012 Jun 11;56(2):594–604. doi: 10.1002/hep.25702

Liver injury in mice gavaged with alcohol and/or HIV protease inhibitors (HIV PIs). RIT, ritonavir (15 mg/kg body weight); LOP, lopinavir (15 mg/kg body weight); (A) Serum alanine aminotransferase (ALT); (B) Liver triglycerides; (C) Liver cholesterol; *p<0.05; **p<0.01; ***p<0.005 compared to control, n=5; (D) Synergistic effects of HIV protease inhibitors on alcohol-induced fat accumulation in the liver of mice gavaged with a liquid alcohol diet alone or mixed with HIV protease inhibitors: RIT and LOP. The red lipid droplets in liver tissue were revealed by Oil Red O staining (200×).

Liver injury in mice gavaged with alcohol and/or HIV protease inhibitors (HIV PIs). RIT, ritonavir (15 mg/kg body weight); LOP, lopinavir (15 mg/kg body weight); (A) Serum alanine aminotransferase (ALT); (B) Liver triglycerides; (C) Liver cholesterol; *p<0.05; **p<0.01; ***p<0.005 compared to control, n=5; (D) Synergistic effects of HIV protease inhibitors on alcohol-induced fat accumulation in the liver of mice gavaged with a liquid alcohol diet alone or mixed with HIV protease inhibitors: RIT and LOP. The red lipid droplets in liver tissue were revealed by Oil Red O staining (200×).