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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Anesthesiology. 2012 Aug;117(2):381–388. doi: 10.1097/ALN.0b013e3182604b2b

Fig. 4. Infraorbital nerve ErbB3 receptor level increases after nerve injury are delayed in neuregulin1 transgenic (Nrg1Tg) rats.

Fig. 4

Infraorbital nerve ErbB3 receptor level was determined by western blot analysis at different time points relevant to behavioral changes in rats with both phenotypes. (A) ErbB3 in wild type rats. ErbB3 receptor levels are shown for wild type (WT) animals with chronic constriction injury (CCI) and the surgical sham groups. (B) For wild type rats, there was no difference in infraorbital nerve ErbB3 receptor expression for the sham and surgery groups in week 1. Statistically significant increases in ErbB3 receptors were observed in week 5 and week 10 after injury in wild type rats with CCI compared to the sham group. (C) ErbB3 in Nrg1Tg rats. ErbB3 receptor levels in Nrg1Tg rats are shown for the CCI and the surgical sham groups. (D) The increase in ErbB3 receptor level in Nrg1Tg rats was not statistically significant compared to the sham group until week 10 after ligation. The increases in infraorbital nerve ErbB3 receptor levels were concurrent with the mechanical threshold changes in response to von Frey fiber stimuli. *p<0.05 vs. CCI group on week 1 in wild type and Nrg1 Tg rats. #p<0.05 vs. sham group in both week 5 and 10 in wild type rats, and week 10 in Nrg1 Tg rats. (mean±S.D)