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. 2012 Apr 19;44(7):424–431. doi: 10.3858/emm.2012.44.7.047

Figure 1.

Figure 1

The obesity CIA enhanced induction of arthritis score and incidence of arthritis. The mice were given either standard chow or a high fat diet from 4 weeks of age. Mice sacrifice was done the first time the mouse weighed 30 g. HFD group exhibited significantly higher serum glucose, cholesterol and triglyceride concentrations than standard chow group. (A) The CII immunization was done the first time when the mouse weighed 30 g. (B, C) The mice were evaluated for the incidence and severity of arthritis. Values are means ± S.E.M. (n = 6). The mean values for the arthritis scores are indicated on the graph. P < 0.01 compared with the saline control. A representative result of at least three independent experiments is shown. (D) Joint sections from the obese CIA and CIA mice were stained with H&E, Safranin O and Toluidine blue (Original magnification of the H&E: 40×; Safranin O and Toluidine blue: 200×).