Table 3.
Associations between plasma concentration of 25(OH)D2 and pQCT parametres
| Vitamin 25(OH)D2 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Minimally adjusted, N = 3,579 (males=1,709) | Anthropometry-adjusted, N = 3,579 (males=1,709) | Anthropometry-, SES- and PA-adjusted, N = 2,247 (males=1,203) | ||||||||
| Beta | 95% CI | P value (sex) | Beta | 95% CI | P value (sex) | Beta | 95% CI | P value (sex) | ||
| Cortical bone mineral density | Male | −0.055 | (−0.099, -0.010) | 0.74 | −0.048 | (−0.091, -0.005) | 0.89 | −0.049 | (−0.101, 0.004) | 0.98 |
| Female | −0.048 | (−0.082, -0.014) | −0.046 | (−0.078, -0.014) | −0.048 | (−0.089, -0.008) | ||||
| ALL | −0.051 | (−0.084, -0.017) | −0.047 | (−0.079, -0.015) | −0.048 | (−0.087, -0.011) | ||||
| Cortical bone area | Male | −0.006 | (−0.055, 0.043) | 0.04 | 0.013 | (−0.021, 0.047) | 0.32 | 0.006 | (−0.038, 0.049) | 0.90 |
| Female | −0.054 | (−0.095, -0.013) | −0.003 | (−0.030, 0.025) | 0.003 | (−0.033, 0.039) | ||||
| ALL | −0.033 | (−0.071, 0.006) | 0.004 | (−0.022, 0.031) | 0.004 | (−0.029, 0.037) | ||||
| Cortical bone mineral content | Male | −0.021 | (−0.074, 0.031) | 0.05 | 0.000 | (−0.035, 0.036) | 0.37 | −0.007 | (−0.053, 0.039) | 0.93 |
| Female | −0.069 | (−0.113, -0.026) | −0.015 | (−0.044, 0.015) | −0.009 | (−0.047, 0.028) | ||||
| ALL | −0.048 | (−0.089, -0.007) | −0.008 | (−0.036, 0.020) | −0.008 | (−0.044, 0.027) | ||||
| Periosteal circumference | Male | 0.018 | (−0.026, 0.062) | 0.08 | 0.035 | (0.002, 0.067) | 0.82 | 0.037 | (−0.007, 0.080) | 0.86 |
| Female | −0.021 | (−0.061, 0.021) | 0.031 | (0.000, 0.063) | 0.041 | (0.003, 0.079) | ||||
| ALL | −0.004 | (−0.040, 0.032) | 0.033 | (0.005, 0.060) | 0.039 | (0.006, 0.075) | ||||
| Endosteal adjusted for periosteal circumference | Male | 0.026 | (−0.012, 0.063) | 0.14 | 0.01 | (−0.024, 0.044) | 0.22 | 0.017 | (−0.025, 0.058) | 0.71 |
| Female | 0.052 | (0.021, 0.082) | 0.029 | (0.001, 0.057) | 0.024 | (−0.009, 0.059) | ||||
| ALL | 0.040 | (0.011, 0.069) | 0.021 | (−0.007, 0.047) | 0.021 | (−0.010, 0.053) | ||||
| Cortical thickness | Male | −0.031 | (−0.085, 0.025) | 0.07 | −0.018 | (−0.065, 0.030) | 0.24 | −0.029 | (−0.088, 0.029) | 0.73 |
| Female | −0.078 | (−0.123, -0.033) | −0.044 | (−0.082, -0.006) | −0.039 | (−0.089, 0.007) | ||||
| ALL | −0.057 | (−0.100, -0.014) | −0.032 | (−0.069, 0.005) | −0.035 | (−0.081, 0.009) | ||||
Table shows associations between plasma concentration of 25(OH)D2 and 50% tibial pQCT parametres at age 15.5 years. Beta coefficients represent SD change in pQCT parametre per doubling of vitamin 25(OH)D2. 95% Confidence intervals are presented with respect to the beta coefficients, P value (sex) shows the difference in associations between males and females. Results are also shown for the following adjustments: minimally adjusted=sex and age at scan; anthropometry adjusted=minimally adjusted+height, loge fat mass and lean mass; anthropometry, SES, PA adjusted=anthropometry-adjusted+maternal and paternal social class, maternal education, and physical activity. All analyses were adjusted for vitamin 25(OH)D3