Table 4.
Associations between plasma concentration of 25(OH)D3 and Pqct parametres
| Vitamin 25(OH)D3 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Minimally adjusted, N = 3,579 (males=1,709) | Anthropometry-adjusted, N = 3,579 (males=1,709) | Anthropometry-, SES- and PA-adjusted, N = 2,247 (males=1,203) | ||||||||
| Beta | 95% CI | P value (sex) | Beta | 95% CI | P value (sex) | Beta | 95% CI | P value (sex) | ||
| Cortical bone mineral density | Male | −0.028 | (−0.124, 0.066) | 0.52 | −0.020 | (−0.110, 0.070) | 0.53 | 0.018 | (−0.103, 0.137) | 0.94 |
| Female | 0.010 | (−0.054, 0.072) | 0.015 | (−0.047, 0.077) | 0.013 | (−0.065, 0.089) | ||||
| ALL | −0.007 | (−0.064, 0.047) | −0.001 | (−0.054, 0.052) | 0.016 | (−0.054, 0.082) | ||||
| Cortical bone area | Male | 0.062 | (−0.043, 0.163) | 0.45 | 0.091 | (0.023, 0.162) | 0.05 | 0.100 | (0.015, 0.191) | 0.22 |
| Female | 0.013 | (−0.064, 0.087) | 0.006 | (−0.047, 0.058) | 0.031 | (−0.034, 0.096) | ||||
| ALL | 0.036 | (−0.028, 0.099) | 0.045 | (0.003, 0.087) | 0.061 | (0.008, 0.116) | ||||
| Cortical bone mineral content | Male | 0.057 | (−0.056, 0.170) | 0.55 | 0.089 | (0.019, 0.162) | 0.08 | 0.105 | (0.014, 0.198) | 0.23 |
| Female | 0.015 | (−0.067, 0.093) | 0.008 | (−0.049, 0.064) | 0.034 | (−0.036, 0.103) | ||||
| ALL | 0.035 | (−0.034, 0.104) | 0.045 | (0.002, 0.090) | 0.066 | (0.009, 0.122) | ||||
| Periosteal circumference | Male | 0.002 | (−0.095, 0.096) | 0.65 | 0.034 | (−0.039, 0.104) | 0.13 | 0.004 | (−0.090, 0.099) | 0.96 |
| Female | −0.027 | (−0.111, 0.054) | −0.038 | (−0.096, 0.021) | 0.001 | (−0.069, 0.068) | ||||
| ALL | −0.013 | (−0.077, 0.047) | −0.005 | (−0.052, 0.039) | 0.002 | (−0.056, 0.059) | ||||
| Endosteal adjusted for periosteal circumference | Male | −0.083 | (−0.161, -0.007) | 0.43 | −0.097 | (−0.164, -0.031) | 0.17 | −0.127 | (−0.214, -0.045) | 0.13 |
| Female | −0.044 | (−0.100, 0.014) | −0.036 | (−0.087, 0.018) | −0.043 | (−0.106, 0.020) | ||||
| ALL | −0.062 | (−0.108, -0.015) | −0.064 | (−0.105, -0.022) | −0.080 | (−0.132, -0.029) | ||||
| Cortical thickness | Male | 0.117 | (0.006, 0.228) | 0.39 | 0.131 | (0.039, 0.226) | 0.21 | 0.180 | (0.061, 0.306) | 0.13 |
| Female | 0.054 | (−0.029, 0.137) | 0.054 | (−0.021, 0.126) | 0.061 | (−0.029, 0.151) | ||||
| ALL | 0.084 | (0.014, 0.152) | 0.089 | (0.031, 0.148) | 0.114 | (0.041, 0.190) | ||||
Table shows associations between plasma concentration of 25(OH)D3 and 50% tibial pQCT parametres at age 15.5 years. Beta coefficients represent SD change in pQCT parametre per doubling of vitamin 25(OH)D3. 95% Confidence intervals are presented with respect to the beta coefficients, P value (sex) shows the difference in associations between males and females. Results are also shown for the following adjustments: minimally adjusted=sex, season of 25(OH)D3 measurement and age at scan; anthropometry-adjusted=minimally adjusted+height, loge fat mass and lean mass; anthropometry-, SES- and PA-adjusted=anthropometry adjusted+maternal and paternal social class, maternal education, and physical activity. All analyses were adjusted for vitamin 25(OH)D2