FIG. 6.

Effect of P-301 on tear output and corneal fluorescein staining in a dry eye animal model. Eyes of animals with induced dry eye were either left untreated (No Tx) or received twice daily topical applications of tear buffer (vehicle), UTP (1%), or P-301 (10⁻³ M). Thereafter, tears (A) were measured in the morning followed by fluorescein staining (B) examination. Buffer or the active compound were applied twice daily, once immediately after the morning tear measurement/fluorescein staining and then again in the afternoon (∼8 h later). Data are means±SEM (n=3). *Denotes a statistically significant difference from baseline. ^#Denotes a statistically significant difference from No Tx, vehicle, and UTP. ^§Denotes a statistically significant difference from No Tx.