Table 1.
Patients enrolled into the study
| 1st challenge | 2nd challenge | ||||||
|---|---|---|---|---|---|---|---|
| Patient | Age/sex | Duration of GFD years | EMA† | Anti-tTG‡ | EMA† | Anti-tTG | Elapsed time (months) between 1st and 2nd challenge |
| Pt 1 | 21/F | 20 | Neg | 2·8 | Neg | 2·8 | 6 |
| Pt 2 | 15/F | 6 | Low Pos | 30·2 | Low Pos | 9·2 | 6 |
| Pt 3 | 15/F | 13 | Neg | 4·8 | Neg | 3·8 | 3 |
| Pt 4 | 18/M | 6 | Neg | 3·2 | Neg | 4·2 | 3 |
| Pt 5 | 16/F | 5 | Neg | 2 | Neg | 2·4 | 3 |
| Pt 6 | 17/M | 16 | Neg | 0·8 | Neg | 0·4 | 10 |
| Pt 7 | 18/M | 17 | Neg | 2 | Neg | 2 | 6 |
| Pt 8 | 19/F | 17 | Neg | n.d. | n.d. | n.d. | n.d. |
| Pt 9 | 17/F | 16 | Neg | 0·4 | Neg | 1·2 | 10 |
| Pt 10 | 20/M | 14 | Neg | 1·8 | Neg | 2·6 | 3 |
| Pt 11 | 19/F | 18 | Low Pos | 38 | Low Pos | 26 | 6 |
| Pt 12 | 22/F | 20 | Low Pos | 5·4 | Low Pos | 7·6 | 3 |
| Pt 13 | 24/F | 14 | Neg | 4 | Neg | 3·6 | 6 |
| Pt 14 | 20/F | 13 | Neg | 0·8 | Neg | 2 | 3 |
†
The serum endomysium (EMA) titres were evaluated before the wheat consumption (day 0) of both 1st and 2nd challenge.
‡
Anti-tissue transglutaminase (anti-tTG) immunoglobulin (Ig)A sensitivity: negative <9 U/ml, weakly positive in the range 9–16 U/ml, positive >16 U/ml. GFD, gluten-free diet; pos, positive; neg, negative; F, female; M, male; n.d., not done.