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. 2012 May 14;590(Pt 13):3019–3034. doi: 10.1113/jphysiol.2012.232942

Figure 2. Calcium-current facilitation is independent of both PKC and PKA.

Figure 2

A, left, DHPG (horizontal bar)-induced calcium-current facilitation in the presence (filled circles; n= 8) and absence (open circles; n= 7) of chelerythrine, a PKC blocker. Right, DHPG-induced calcium-current facilitation in the presence of Bis I, a PKC inhibitor (filled circles; n = 7) and Bis V, an inactive analogue of Bis I (open circles; n= 7). B, left, summary of the DHPG-induced calcium-current facilitation in the presence of PKA inhibitors, intracellularly applied PKI 6–22 (PKI: n= 9; control: n= 6), bath-applied myristoylated PKI 14–22 (PKI: n= 7; control: n= 6), Rp-cAMPS (Rp-cAMPS: n= 6; control: n= 7) and H89 (H89: n= 11; control: n= 12). The facilitation ratio was normalized to that in the control experiment for each drug. *P < 0.05. Right, the time course of the DHPG-induced calcium-current facilitation in the presence (filled circles) and the absence (open circles) of bath-applied myristoylated PKI 14–22.