Figure 7. The model for the mGluR5–InsP₃R–L-VDCC complex.

mGluR5, InsP₃Rs and L-VDCCs constitute a large protein complex, which is tethered to the scaffold protein Homer. This protein complex enables the efficient functional coupling between each component. Activation of mGluR5 generates the second messenger InsP₃, which acts on InsP₃Rs synergistically with calcium entering through L-VDCCs, leading to the amplification of calcium signalling.